Contains proanthocyanidins that inhibit angiotensin converting enzyme (ACE), an enzyme that converts angiotensin I to angiotensin II, a potent vasoconstrictor, thus increasing the oxygen supply to the myocardium.
Drug Interactions: Potentiates the actions of digitalis (extract of Digitalis purpurea), a powerful cardiac stimulant and diuretic. May interact with existing treatment for cardiovascular disorders including hypertension, hypotension, arrhythmia, ischemia, etc. There is a potential risk of increased hypertension when used with beta-adrenoceptor blocking drugs. Possible potentiation of sympathomimetics and an increased risk of hypertension. Cardioactives may potentiate cardiac glycosides, interfere or antagonize antiarrhythmic drugs, increase the risk of hypokalemia, antagonize beta-adrenoceptor blocking drugs, interact with depolarizing muscle relaxants and increase the risk of arrhythmias, interfere with nitrates and calcium-channel blockers, and cardioactives may increase the arrhythmogenic potential of terfenadine. Due to the diuretic action of this herb the following drug interactions are possible: increased risk of toxicity with anti-inflammatory analgesics; if hypokalemia occurs possible antagonism with antiarrhythmics and potentiation of muscle relaxants; antagonizes antidiabetic (hypoglycemic) drugs; may potentiate and/or interfere with antihypertensives; may potentiate lithium therapy; when taken with corticosteroids there is a risk for hypokalemia; may potentiate other diuretics and increase the risk of hypokalemia. Due to the antihypertensive (hypotensive) action of this herb the following interactions are possible: when taken with anesthetics an increased hypotensive effect; potentiation of antihypertensives; when taken with diuretics difficulty with diuresis and hypertension may result; antagonism of sympathomimetics.
Safety: Safe when used appropriately.
Side Effects: (Possible adverse effects and/or overdose effects) Possible nausea, difficulty breathing, fatigue, sweating, rash on the hands. May cause arrhythmia and congestive heart failure. Large doses may cause CNS depression and hypotention.
Warning: Take immediately after a meal in order to avoid nausea.